Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 3/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | POLA1 | P09884 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29295655 | 1.00 | RAB9A (0.37) | RAB9ABACE1NR1H2NR1H3MCHR1 | |
| SCHEMBL29295648 | 0.93 | NR1H2 (0.35) | RAB9ABACE1NR1H2NR1H3MCHR1 | |
| SCHEMBL21569827 | 0.92 | NR1H2 (0.34) | RAB9ABACE1NR1H2NR1H3MCHR1 | |
| SCHEMBL29296723 | 0.91 | NR1H2 (0.43) | NR1H2NR1H3POLA1 | |
| SCHEMBL29292400 | 0.90 | NR1H2 (0.46) | RAB9ANR1H2NR1H3POLA1 | |
| SCHEMBL29292376 | 0.88 | NR1H2 (0.38) | NR1H2NR1H3POLA1CYP3A4CYP2C19 | |
| SCHEMBL29292359 | 0.84 | NR1H2 (0.43) | NR1H2NR1H3POLA1 | |
| SCHEMBL29297676 | 0.83 | NR1H2 (0.38) | NR1H2NR1H3POLA1 | |
| SCHEMBL29292394 | 0.82 | NR1H2 (0.36) | RAB9ABACE1NR1H2NR1H3MCHR1 | |
| SCHEMBL21569998 | 0.79 | NR1H2 (0.45) | NR1H2NR1H3POLA1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883926-B1 | BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDE DERIVATIVES AND PROTEIN CONJUGATES THEREOF FOR USE AS LXR AGONISTS | REGENERON PHARMA (US) | 2024-07-10 | — | — | EP | disclosed |