Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NMT1 | P30419 | 1/20 | 0.42 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19392163 | 0.82 | MAPT (0.45) | MAPTTDP1TGM2POLBGAA | |
| SCHEMBL22177099 | 0.81 | TDP1 (0.47) | MAPTTDP1TGM2POLBKDM4E | |
| SCHEMBL18461277 | 0.80 | MAPT (0.67) | MAPTTDP1TGM2POLBGAA | |
| SCHEMBL18890669 | 0.79 | TDP1 (0.58) | MAPTTDP1TGM2POLBKDM4E | |
| SCHEMBL13653867 | 0.78 | IDO1 (0.45) | MAPTPOLBGAAKDM4EHPGD | |
| SCHEMBL12035256 | 0.76 | TDP1 (0.60) | MAPTTDP1TGM2POLBKDM4E | |
| SCHEMBL5838724 | 0.74 | GRIN2D (0.54) | MAPTTDP1TGM2POLBGAA | |
| SCHEMBL5838730 | 0.74 | GRIN2D (0.54) | MAPTTDP1TGM2POLBGAA | |
| SCHEMBL678436 | 0.73 | TDP1 (0.56) | MAPTTDP1TGM2POLBKDM4E | |
| SCHEMBL18483397 | 0.73 | TDP1 (0.41) | MAPTTDP1TGM2POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3143026-B1 | COMPOUNDS AND COMPOSITIONS FOR INDUCING CHONDROGENESIS | NOVARTIS AG (CH) | 2024-07-10 | — | — | EP | disclosed |