SCHEMBL5838730

SCHEMBL5838730

CC(=CC(C)=Nc1ccc(C)cc1)Nc1ccc(C)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRIN2D O15399 2/20 0.54
GRIN3B O60391 2/20 0.54
GRIN1 Q05586 2/20 0.54
GRIN2A Q12879 2/20 0.54
GRIN2B Q13224 2/20 0.54
GRIN2C Q14957 2/20 0.54
GRIN3A Q8TCU5 2/20 0.54
SIGMAR1 Q99720 2/20 0.54
MAPT P10636 5/20 0.51
TDP1 Q9NUW8 1/20 0.44
PLAU P00749 2/20 0.41
HTR3E A5X5Y0 1/20 0.41
SLC22A2 O15244 1/20 0.41
SLC22A1 O15245 1/20 0.41
SLC22A3 O75751 1/20 0.41
HTR3B O95264 1/20 0.41
HTR3A P46098 1/20 0.41
HTR3D Q70Z44 1/20 0.41
HTR3C Q8WXA8 1/20 0.41
HTT P42858 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5838724 1.00 GRIN2D (0.54) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL5682229 0.83 MAPT (0.44) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL15312983 0.81 MAPT (0.56) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL15312985 0.81 MAPT (0.56) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL5681448 0.81 MAPT (0.56) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL15312987 0.81 MAPT (0.56) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL5681453 0.81 MAPT (0.56) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL4109674 0.76 GRIN2D (0.63) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL4109679 0.76 GRIN2D (0.63) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B
SCHEMBL5032779 0.76 HTR3E (0.48) GRIN2DGRIN3BGRIN1GRIN2AGRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1229055-A1 Process for the gas-phase (co)-polymerisation of olefins in a fluidised bed reactor BP Chemicals S.N.C. (FR) 2002-08-07 EP claimed
US-6992034-B2 Catalyst component for olefin polymerization FORMOSA PLASTICS CORPORATION, U.S.A. (US) 2006-01-31 US disclosed
US-20050009690-A1 Catalyst component for olefin polymerization FORMOSA PLASTICS CORPORATIONS, U.S.A. 2005-01-13 US disclosed
US-6500906-B1 MGCL2 IN SPHERICAL SHAPE AS SUPPORT; NARROW MOLECULAR WEIGHT DISTRIBUTION; SAMSUNG GENERAL CHEMICALS (KR) 2002-12-31 US disclosed
EP-1229055-A1 Process for the gas-phase (co)-polymerisation of olefins in a fluidised bed reactor BP Chemicals S.N.C. (FR) 2002-08-07 EP disclosed