Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 13/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.41 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930271 | 0.92 | CHRM1 (0.44) | CHRM1HCRTR1HCRTR2CFDPDE4B | |
| SCHEMBL2929940 | 0.92 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL2928729 | 0.89 | HCRTR1 (0.42) | HCRTR1HCRTR2 | |
| SCHEMBL2955879 | 0.88 | HCRTR2 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL2931403 | 0.88 | HCRTR2 (0.46) | CHRM1HCRTR1HCRTR2CFDPDE4B | |
| SCHEMBL3415862 | 0.88 | HCRTR2 (0.46) | CHRM1HCRTR1HCRTR2CFDPDE4B | |
| SCHEMBL3415863 | 0.88 | HCRTR2 (0.46) | CHRM1HCRTR1HCRTR2CFDPDE4B | |
| SCHEMBL2931529 | 0.86 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL2927512 | 0.86 | CYP46A1 (0.41) | HCRTR1HCRTR2 | |
| SCHEMBL2929614 | 0.85 | CHRM1 (0.46) | CHRM1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |