Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | CFD | P00746 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929613 | 0.92 | CHRM1 (0.44) | CHRM1HCRTR1HCRTR2CFDPDE4B | |
| SCHEMBL2924872 | 0.92 | HDAC7 (0.36) | CHRM1HCRTR1HCRTR2 | |
| SCHEMBL2926153 | 0.89 | HDAC7 (0.44) | HCRTR1HCRTR2 | |
| SCHEMBL2925061 | 0.88 | HCRTR2 (0.41) | HCRTR1HCRTR2PDE4BRAB9A | |
| SCHEMBL3415863 | 0.88 | HCRTR2 (0.46) | CHRM1HCRTR1HCRTR2CFDPDE4B | |
| SCHEMBL3415862 | 0.88 | HCRTR2 (0.46) | CHRM1HCRTR1HCRTR2CFDPDE4B | |
| SCHEMBL2931403 | 0.88 | HCRTR2 (0.46) | CHRM1HCRTR1HCRTR2CFDPDE4B | |
| SCHEMBL2925882 | 0.86 | RXRA (0.33) | CHRM1HCRTR1HCRTR2 | |
| SCHEMBL2931138 | 0.86 | HCRTR1 (0.40) | HCRTR1HCRTR2BTKNPC1ALDH1A1 | |
| SCHEMBL2924235 | 0.86 | POLB (0.39) | HCRTR1HCRTR2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | claimed |
| US-20100016401-A1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | Actelion Phamaceuticals Ltd. (CH) | 2010-01-21 | — | — | US | claimed |
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |
| US-20100016401-A1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | Actelion Phamaceuticals Ltd. (CH) | 2010-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100016401-A1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | HCRTR1, HCRTR2, CNR1 | CHRM1 139/4885HCRTR1 1/4885HCRTR2 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.