Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.41 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.38 |
| ▸ | FURIN | P09958 | 11/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
| ▸ | PCSK6 | P29122 | 1/20 | 0.34 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.34 |
| ▸ | NPY4R | P50391 | 3/20 | 0.32 |
| ▸ | NPY1R | P25929 | 2/20 | 0.32 |
| ▸ | NPY2R | P49146 | 2/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22788836 | 0.91 | FURIN (0.36) | SIRT5KISS1RFURINSIRT2PCSK6 | |
| SCHEMBL21153627 | 0.89 | SIRT5 (0.37) | SIRT5FURINSIRT2PCSK6PRSS1 | |
| SCHEMBL22788736 | 0.89 | FURIN (0.37) | SIRT5FURINSIRT2SIRT6SIRT1 | |
| SCHEMBL26894580 | 0.88 | SIRT5 (0.37) | SIRT5FURINSIRT2PCSK6PRSS1 | |
| SCHEMBL27067717 | 0.87 | SIRT5 (0.45) | SIRT5FURINSIRT2 | |
| SCHEMBL21153628 | 0.87 | SIRT5 (0.45) | SIRT5FURINSIRT2 | |
| SCHEMBL16091799 | 0.86 | SIRT5 (0.36) | SIRT5KISS1RFURINSIRT6SIRT1 | |
| SCHEMBL18661755 | 0.86 | SIRT5 (0.36) | SIRT5KISS1RFURINSIRT6SIRT1 | |
| SCHEMBL21103418 | 0.86 | SIRT5 (0.36) | SIRT5KISS1RFURINSIRT6SIRT1 | |
| SCHEMBL15499691 | 0.86 | SIRT5 (0.36) | SIRT5KISS1RFURINSIRT6SIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3883926-B1 | BIS-OCTAHYDROPHENANTHRENE CARBOXAMIDE DERIVATIVES AND PROTEIN CONJUGATES THEREOF FOR USE AS LXR AGONISTS | REGENERON PHARMA (US) | 2024-07-10 | — | — | EP | disclosed |