Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 11/20 | 0.37 |
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.37 |
| ▸ | PCSK6 | P29122 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.33 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26243854 | 0.91 | FURIN (0.37) | FURINSIRT5PCSK6PRSS1CTSL | |
| SCHEMBL21153627 | 0.91 | SIRT5 (0.37) | FURINSIRT5PCSK6SIRT2PRSS1 | |
| SCHEMBL22788836 | 0.89 | FURIN (0.36) | FURINSIRT5PCSK6SIRT2PRSS1 | |
| SCHEMBL29296435 | 0.89 | SIRT5 (0.41) | FURINSIRT5PCSK6SIRT2PRSS1 | |
| SCHEMBL27067717 | 0.88 | SIRT5 (0.45) | FURINSIRT5SIRT2 | |
| SCHEMBL21153628 | 0.88 | SIRT5 (0.45) | FURINSIRT5SIRT2 | |
| SCHEMBL22788819 | 0.88 | NPY5R (0.37) | FURINSIRT5SIRT2SIRT6SIRT1 | |
| SCHEMBL20375788 | 0.87 | SIRT5 (0.36) | FURINSIRT5SIRT6SIRT1LMNA | |
| SCHEMBL16091799 | 0.87 | SIRT5 (0.36) | FURINSIRT5SIRT6SIRT1LMNA | |
| SCHEMBL15499691 | 0.87 | SIRT5 (0.36) | FURINSIRT5SIRT6SIRT1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020257235-A1 | 1-(4-(AMINOMETHYL)BENZYL)-2-BUTYL-2H-PYRAZOLO[3,4-C]QUINOLIN-4-AMINE DERIVATIVES AND RELATED COMPOUNDS AS TOLL-LIKE RECEPTOR (TLR) 7/8 AGONISTS, AS WELL AS ANTIBODY DRUG CONJUGATES THEREOF FOR USE IN CANCER THERAPY AND DIAGNOSIS | SUTRO BIOPHARMA, INC. (US) | 2020-12-24 | — | — | WO | disclosed |
| WO-2020252043-A1 | 5H-PYRROLO[3,2-d]PYRIMIDINE-2,4-DIAMINO COMPOUNDS AND ANTIBODY CONJUGATES THEREOF | SUTRO BIOPHARMA, INC. (US) | 2020-12-17 | — | — | WO | disclosed |
| WO-2020252015-A1 | IMMUNOMODULATOR ANTIBODY DRUG CONJUGATES AND USES THEREOF | SUTRO BIOPHARMA, INC. (US) | 2020-12-17 | — | — | WO | disclosed |