Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.73 |
| ▸ | IDO1 | P14902 | 3/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | BCL6 | P41182 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CTH | P32929 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521069 | 0.81 | IDO1 (0.70) | SMN1; SMN2HTTIDO1ALDH1A1HDAC2 | |
| SCHEMBL2794397 | 0.80 | IDO1 (1.00) | SMN1; SMN2HTTIDO1ALDH1A1KMT2A | |
| SCHEMBL525715 | 0.80 | ALDH1A1 (0.56) | SMN1; SMN2HTTIDO1ALDH1A1BCL6 | |
| SCHEMBL14724332 | 0.77 | IDO1 (0.47) | SMN1; SMN2HTTIDO1ALDH1A1BCL6 | |
| SCHEMBL428550 | 0.76 | HDAC8 (0.58) | SMN1; SMN2HDAC2HDAC8HDAC6KMT2A | |
| SCHEMBL48869 | 0.76 | POLB (0.60) | SMN1; SMN2HTTALDH1A1HDAC2HDAC8 | |
| SCHEMBL25784651 | 0.76 | HDAC2 (0.61) | SMN1; SMN2HDAC2HDAC8HDAC6KMT2A | |
| SCHEMBL3558312 | 0.74 | MEN1 (0.63) | SMN1; SMN2BCL6HDAC2HDAC8HDAC6 | |
| SCHEMBL30208757 | 0.74 | MEN1 (0.63) | SMN1; SMN2BCL6HDAC2HDAC8HDAC6 | |
| SCHEMBL12313357 | 0.74 | HDAC2 (0.56) | SMN1; SMN2ALDH1A1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227233-A2 | IDO INHIBITORS | Newlink Genetics (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009073620-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-06-11 | — | — | WO | claimed |