Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.63 |
| ▸ | NPC1 | O15118 | 3/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10566671 | 0.89 | IDO1 (0.81) | IDO1RAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL2930725 | 0.84 | IDO1 (0.72) | IDO1RAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL1521069 | 0.82 | IDO1 (0.70) | IDO1RAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2932575 | 0.82 | IDO1 (0.70) | IDO1RAB9ASMN1; SMN2LMNAGAA | |
| SCHEMBL2792097 | 0.82 | IDO1 (0.70) | IDO1RAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL2794062 | 0.81 | IDO1 (1.00) | IDO1RAB9ASMN1; SMN2MAOAMAOB | |
| SCHEMBL1520731 | 0.80 | IDO1 (0.67) | IDO1RAB9ASMN1; SMN2NPC1GAA | |
| SCHEMBL2929102 | 0.80 | IDO1 (0.67) | IDO1SMN1; SMN2LMNATAAR1MAPT | |
| SCHEMBL2930645 | 0.80 | SMN1; SMN2 (0.73) | IDO1RAB9ASMN1; SMN2NPC1LMNA | |
| SCHEMBL28355289 | 0.80 | IDO1 (0.67) | IDO1RAB9ASMN1; SMN2NPC1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100166881-A1 | Novel IDO Inhibitors and Methods of Use Thereof | PRENDERGAST GEORGE C | 2010-07-01 | — | — | US | claimed |
| EP-1940787-A4 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | LANKENAU INST MEDICAL RES (US) | 2009-07-01 | — | — | EP | claimed |
| EP-1940787-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | Lankenau Institute for Medical Research (US) | 2008-07-09 | — | — | EP | claimed |
| US-20070105907-A1 | Novel IDO inhibitors and methods of use thereof | LANKENAU INSTITUTE FOR MEDICAL RESEARCH | 2007-05-10 | — | — | US | claimed |
| WO-2007050963-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2007-05-03 | — | — | WO | claimed |
| US-20100166881-A1 | Novel IDO Inhibitors and Methods of Use Thereof | PRENDERGAST GEORGE C | 2010-07-01 | — | — | US | disclosed |
| US-7705022-B2 | N-[2-(Indol-3-yl)ethyl]-S-methyl-dithiocarbamate; N-[2-(benzo[b]thiophen-3-yl)ethyl]-S-methyl-dithiocarbamate; N-[2-(indol-3-yl)ethyl]-S[(naphth-2-yl)methyl]-dithiocarbamate; anticarcinogenic agents; free of brassinin | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2010-04-27 | — | — | US | disclosed |
| EP-1940787-A4 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | LANKENAU INST MEDICAL RES (US) | 2009-07-01 | — | — | EP | disclosed |
| EP-1940787-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | Lankenau Institute for Medical Research (US) | 2008-07-09 | — | — | EP | disclosed |
| US-20070105907-A1 | Novel IDO inhibitors and methods of use thereof | LANKENAU INSTITUTE FOR MEDICAL RESEARCH | 2007-05-10 | — | — | US | disclosed |
| WO-2007050963-A1 | NOVEL IDO INHIBITORS AND METHODS OF USE THEREOF | LANKENAU INSTITUTE FOR MEDICAL RESEARCH (US) | 2007-05-03 | — | — | WO | disclosed |
| EP-0656351-B1 | Dithiocarbonimide derivatives as fungicides, insecticides, and acaricides | SUMITOMO CHEMICAL CO (JP) | 1998-04-15 | — | — | EP | disclosed |
| US-5563159-A | Dithiocarbonimide derivatives useful as acaricidal, fungicidal, and insecticidal agents | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1996-10-08 | — | — | US | disclosed |
| EP-0656351-A1 | Dithiocarbonimide derivatives as fungicides, insecticides, and acaricides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1995-06-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100166881-A1 | Novel IDO Inhibitors and Methods of Use Thereof | IDO1, IDO2, INMT | IDO1 1/4885RAB9A 4439/4885SMN1; SMN2 4647/4885 |
| US-20070105907-A1 | Novel IDO inhibitors and methods of use thereof | IDO1, IDO2, INMT | IDO1 1/4885RAB9A 4439/4885SMN1; SMN2 4647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.