Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 5/20 | 0.72 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | PLAAT3 | P53816 | 2/20 | 0.45 |
| ▸ | PLAAT5 | Q96KN8 | 2/20 | 0.45 |
| ▸ | PLAAT2 | Q9NWW9 | 2/20 | 0.45 |
| ▸ | PLAAT4 | Q9UL19 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932575 | 0.84 | IDO1 (0.70) | IDO1RAB9ASMN1; SMN2CNR1GAA | |
| SCHEMBL2792097 | 0.84 | IDO1 (0.70) | IDO1NPC1RAB9ASMN1; SMN2CNR1 | |
| SCHEMBL2794397 | 0.84 | IDO1 (1.00) | IDO1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL2930785 | 0.81 | LMNA (0.66) | IDO1SMN1; SMN2KMT2ALMNAALOX12 | |
| SCHEMBL1521069 | 0.81 | IDO1 (0.70) | IDO1NPC1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL3912629 | 0.78 | IDO1 (0.68) | IDO1NPC1RAB9ASMN1; SMN2CNR1 | |
| SCHEMBL30439849 | 0.77 | KMT2A (0.47) | IDO1NPC1RAB9ASMN1; SMN2PLAAT3 | |
| SCHEMBL1520511 | 0.77 | IDO1 (0.51) | IDO1NPC1RAB9AGAATP53 | |
| SCHEMBL10566671 | 0.74 | IDO1 (0.81) | IDO1NPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL16681873 | 0.73 | NPC1 (0.74) | NPC1RAB9ASMN1; SMN2CNR1PLAAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227233-A2 | IDO INHIBITORS | Newlink Genetics (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009073620-A2 | IDO INHIBITORS | NEWLINK GENETICS (US) | 2009-06-11 | — | — | WO | claimed |