Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.49 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9229133 | 1.00 | TLR8 (0.49) | TLR8TLR7SLC9A1KDRMPO | |
| SCHEMBL254046 | 0.98 | TLR8 (0.50) | TLR8TLR7SLC9A1KDRMPO | |
| SCHEMBL18073162 | 0.93 | TLR8 (0.55) | TLR8TLR7SLC9A1MPOMEN1 | |
| SCHEMBL10123647 | 0.86 | SLC6A2 (0.44) | TLR8TLR7SLC9A1MEN1CYP1A2 | |
| SCHEMBL9038635 | 0.79 | SLC9A1 (0.44) | TLR8TLR7SLC9A1MEN1KMT2A | |
| SCHEMBL17981794 | 0.79 | PDE4D (0.42) | TLR8TLR7MPOMEN1KMT2A | |
| SCHEMBL28267672 | 0.79 | KMT2A (0.41) | TLR8TLR7MEN1CYP1A2CYP2C19 | |
| SCHEMBL30177201 | 0.79 | IRAK4 (0.43) | TLR8TLR7MPOKMT2AMAPT | |
| SCHEMBL30995445 | 0.78 | ENPP2 (0.42) | TLR8KDRMEN1KMT2A | |
| SCHEMBL5764690 | 0.78 | SLC6A2 (0.43) | TLR8TLR7SLC9A1MEN1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240228469-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2024-07-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240228469-A1 | PCSK9 INHIBITORS AND METHODS OF USE THEREOF | PCSK9, PCSK7, PCSK6 | TLR8 2721/4885TLR7 1185/4885SLC9A1 3564/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.