Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 9/20 | 0.44 |
| ▸ | MERTK | Q12866 | 9/20 | 0.44 |
| ▸ | GAS6 | Q14393 | 9/20 | 0.44 |
| ▸ | FLT3 | P36888 | 8/20 | 0.44 |
| ▸ | AXL | P30530 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4768640 | 0.81 | POLB (0.49) | POLBSIRT5SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2023032 | 0.81 | MKNK1 (0.58) | TYRO3MERTKFLT3 | |
| SCHEMBL29313687 | 0.80 | POLB (0.41) | POLBSIRT5TYRO3MERTKGAS6 | |
| SCHEMBL19476565 | 0.80 | MERTK (0.62) | TYRO3MERTKGAS6FLT3AXL | |
| SCHEMBL19476573 | 0.80 | MERTK (0.56) | POLBTYRO3MERTKGAS6FLT3 | |
| SCHEMBL1936209 | 0.79 | KDR (0.56) | MERTKFLT3AXL | |
| SCHEMBL4769260 | 0.76 | CA2 (0.48) | — | |
| SCHEMBL4763724 | 0.76 | CA2 (0.47) | — | |
| SCHEMBL2025331 | 0.75 | SMN1; SMN2 (0.45) | POLBSMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL13737291 | 0.75 | L3MBTL1 (0.40) | POLBTYRO3MERTKGAS6FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3782986-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-10 | — | — | EP | disclosed |