Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 8/20 | 0.48 |
| ▸ | HCRTR2 | O43614 | 7/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 8/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415866 | 1.00 | HCRTR1 (0.48) | HCRTR1HCRTR2CHRM1CHRM3CHRM2 | |
| SCHEMBL2924532 | 0.88 | SLC6A4 (0.40) | HCRTR1HCRTR2 | |
| SCHEMBL2930272 | 0.88 | CHRM1 (0.46) | HCRTR1HCRTR2CHRM1CHRM3RORC | |
| SCHEMBL2929614 | 0.88 | CHRM1 (0.46) | HCRTR1HCRTR2CHRM1 | |
| SCHEMBL3415643 | 0.88 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL2930541 | 0.88 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL2926961 | 0.87 | MEN1 (0.43) | HCRTR1HCRTR2CHRM3 | |
| SCHEMBL3414068 | 0.87 | MEN1 (0.43) | HCRTR1HCRTR2CHRM3 | |
| SCHEMBL3416000 | 0.87 | HCRTR1 (0.50) | HCRTR1HCRTR2CHRM3 | |
| SCHEMBL2930074 | 0.85 | SLC6A7 (0.35) | HCRTR1HCRTR2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | claimed |
| EP-2079690-B1 | 3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-09-15 | — | — | EP | disclosed |