Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 17/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 16/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930541 | 1.00 | HCRTR1 (0.46) | HCRTR1TSHRRECQLHCRTR2 | |
| SCHEMBL2450567 | 0.92 | HCRTR1 (0.42) | HCRTR1TSHRRECQLHCRTR2 | |
| SCHEMBL2925288 | 0.92 | HCRTR1 (0.46) | HCRTR1TSHRRECQLHCRTR2 | |
| SCHEMBL3415834 | 0.92 | HCRTR1 (0.46) | HCRTR1TSHRRECQLHCRTR2 | |
| SCHEMBL2924532 | 0.91 | SLC6A4 (0.40) | HCRTR1TSHRRECQLHCRTR2 | |
| SCHEMBL3417003 | 0.91 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL2931897 | 0.91 | HCRTR1 (0.45) | HCRTR1HCRTR2 | |
| SCHEMBL2923800 | 0.89 | HCRTR1 (0.48) | HCRTR1HCRTR2 | |
| SCHEMBL3415866 | 0.88 | HCRTR1 (0.48) | HCRTR1HCRTR2 | |
| SCHEMBL2931080 | 0.88 | HCRTR1 (0.42) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | claimed |
| EP-2185512-B1 | TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-12-29 | — | — | EP | disclosed |