Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.52 |
| ▸ | ATR | Q13535 | 2/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | ERN1 | O75460 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.48 |
| ▸ | ROS1 | P08922 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2932360 | 0.88 | MKNK1 (0.60) | CHEK1HPGDRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL2933714 | 0.81 | HPGD (0.55) | HPGDSMN1; SMN2ALDH1A1TP53ATR | |
| SCHEMBL2933173 | 0.81 | HPGD (0.50) | HPGDSMN1; SMN2ALDH1A1MKNK1MKNK2 | |
| SCHEMBL2936901 | 0.80 | FASN (0.53) | HPGDSMN1; SMN2PIK3CAPLK4JAK2 | |
| SCHEMBL2929014 | 0.80 | PHGDH (0.57) | HPGDSMN1; SMN2ALDH1A1MKNK1MKNK2 | |
| SCHEMBL16420505 | 0.79 | ATR (0.71) | HPGDRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL1679573 | 0.79 | KMT2A (0.59) | HPGDRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2927132 | 0.78 | MKNK1 (0.62) | HPGDRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2927882 | 0.78 | RIPK1 (0.55) | HPGDSMN1; SMN2MKNK1MKNK2ATR | |
| Hydrochloric Acid SCHEMBL2935656 | 0.77 | RIPK1 (0.54) | HPGDSMN1; SMN2MKNK1MKNK2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044051-B1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB PUBL (SE) | 2010-01-27 | — | — | EP | disclosed |
| EP-2044051-B1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB PUBL (SE) | 2010-01-27 | — | — | EP | disclosed |
| US-20080039450-A1 | Compounds | BIOVITRUM AB (PUBL.) (SE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039450-A1 | Compounds | BIOVITRUM AB (PUBL.) (SE) | 2008-02-14 | — | — | US | disclosed |
| US-20080039450-A1 | Compounds | BIOVITRUM AB (PUBL.) (SE) | 2008-02-14 | — | — | US | disclosed |
| WO-2007147874-A1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB (PUBL) (SE) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039450-A1 | Compounds | NEK2, CSNK2A3, CSNK2A1 | CHEK1 162/4885HPGD 3066/4885RAB9A 1528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.