Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 7/20 | 0.47 |
| ▸ | LIPE | Q05469 | 6/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31009186 | 0.85 | POLQ (0.44) | POLQLIPEGPBAR1 | |
| SCHEMBL29314374 | 0.85 | POLQ (0.44) | POLQLIPEGPBAR1 | |
| SCHEMBL29314384 | 0.85 | POLQ (0.52) | POLQLIPETLR7LMNANPSR1 | |
| SCHEMBL29314395 | 0.84 | POLQ (0.43) | POLQLIPETLR7LMNANPSR1 | |
| SCHEMBL30847596 | 0.83 | POLQ (0.50) | POLQLIPETLR7LMNANPSR1 | |
| SCHEMBL29314388 | 0.83 | POLQ (0.50) | POLQLIPETLR7LMNANPSR1 | |
| SCHEMBL29314065 | 0.77 | POLQ (0.44) | POLQLIPETLR7LMNANPSR1 | |
| SCHEMBL29314067 | 0.76 | POLQ (0.43) | POLQLIPETLR7 | |
| SCHEMBL29314066 | 0.76 | POLQ (0.43) | POLQLIPETLR7NPSR1 | |
| SCHEMBL30847641 | 0.74 | POLQ (0.43) | POLQLIPETLR7LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |
| WO-2024147972-A2 | DNA POLYMERASE THETA INHIBITORS CONTAINING NON-SATURATED 5-MEMBERED HETEROCYCLIC RINGS AND USE THEREOF | THOMAS JEFFERSON UNIVERSITY (US) | 2024-07-11 | — | — | WO | disclosed |