Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | CACNA1I | Q9P0X4 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12788374 | 0.94 | HSD11B1 (0.39) | ALDH1A1SMN1; SMN2KCNH2CHRM2HTR1A | |
| SCHEMBL19958953 | 0.92 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KCNH2CHRM2HTR1A | |
| SCHEMBL10159897 | 0.90 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KCNH2CHRM2HTR1A | |
| SCHEMBL824037 | 0.86 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2KCNH2CHRM2HTR1A | |
| SCHEMBL19958939 | 0.85 | ALDH1A1 (0.41) | ALDH1A1SMN1; SMN2KCNH2CHRM2HTR1A | |
| SCHEMBL12788388 | 0.84 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2KCNH2CHRM2HTR1A | |
| SCHEMBL13656337 | 0.84 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KCNH2CHRM2HTR1A | |
| SCHEMBL2734116 | 0.84 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2KCNH2CHRM2HTR1A | |
| SCHEMBL22560689 | 0.83 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2KCNH2CHRM2HTR1A | |
| SCHEMBL1220049 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | ARVINAS OPERATIONS, INC. (US) | 2024-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12036209-B2 | Compounds and methods for the targeted degradation of Interleukin-1 receptor-associated kinase 4 polypeptides | IRAK1, IRAK4, IRAK2 | ALDH1A1 2211/4885SMN1; SMN2 1811/4885KCNH2 4850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.