Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 2/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 5/20 | 0.40 |
| ▸ | BCR | P11274 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2935031 | 0.91 | PIM3 (0.40) | PIM3HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL2933931 | 0.90 | PIM3 (0.53) | PIM3HDAC4HDAC2HDAC8HDAC6 | |
| Trifluoroacetic Acid SCHEMBL2931457 | 0.88 | FASN (0.46) | FASNPIM3HDAC4HDAC2HDAC8 | |
| SCHEMBL13515277 | 0.87 | FASN (0.50) | FASNPIM3ABL1BCRMKNK1 | |
| Trifluoroacetic Acid SCHEMBL2933929 | 0.80 | PIM3 (0.51) | PIM3HDAC4HDAC2HDAC8HDAC6 | |
| Trifluoroacetic Acid SCHEMBL2935027 | 0.79 | MKNK1 (0.41) | PIM3HDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL13515311 | 0.78 | PIM3 (0.54) | PIM3KCNH2MKNK1MKNK2DYRK1A | |
| SCHEMBL13515300 | 0.77 | MKNK1 (0.46) | FASNABL1BCRMKNK1MKNK2 | |
| SCHEMBL2934437 | 0.76 | TTK (0.52) | PIM3DYRK1A | |
| SCHEMBL2932525 | 0.76 | LRRK2 (0.46) | ABL1BCRMKNK1MKNK2ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2044051-B1 | PYRIDINE AND PYRAZINE DERIVATIVES AS MNK KINASE INHIBITORS | BIOVITRUM AB PUBL (SE) | 2010-01-27 | — | — | EP | disclosed |
| US-20080039450-A1 | Compounds | BIOVITRUM AB (PUBL.) (SE) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039450-A1 | Compounds | NEK2, CSNK2A3, CSNK2A1 | FASN 4597/4885PIM3 2131/4885HDAC4 1040/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.