Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 7/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.33 |
| ▸ | HSPA8 | P11142 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.32 |
| ▸ | KLK1 | P06870 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29317471 | 0.86 | NPC1 (0.43) | NPC1METKDRDHFRHDAC6 | |
| SCHEMBL29314302 | 0.82 | NPC1 (0.43) | NPC1METKDRDHFRHDAC6 | |
| SCHEMBL29314367 | 0.82 | HDAC6 (0.38) | NPC1KDRDHFRHDAC6ALOX5 | |
| SCHEMBL21167629 | 0.81 | NPC1 (0.44) | NPC1METKDRDHFRHDAC6 | |
| SCHEMBL21167442 | 0.81 | PIK3CA (0.42) | NPC1BRAFKDRDHFRHDAC6 | |
| SCHEMBL29314497 | 0.80 | HDAC6 (0.41) | NPC1KDRHDAC6ALOX5KLKB1 | |
| SCHEMBL21167454 | 0.80 | NPC1 (0.44) | NPC1METKDRDHFRHDAC6 | |
| SCHEMBL21167657 | 0.79 | NPC1 (0.42) | NPC1METKDRDHFRHDAC6 | |
| SCHEMBL21167525 | 0.79 | BRAF (0.41) | NPC1METBRAFKDRDHFR | |
| SCHEMBL21167366 | 0.79 | NPC1 (0.43) | NPC1METKDRDHFRHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3893872-B1 | ORGANOPHOSPHORUS-SUBSTITUTED COMPOUNDS AS C-MET INHIBITORS AND THERAPEUTIC USES THEREOF | BETA PHARMA INC (US) | 2024-07-17 | — | — | EP | disclosed |