Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 7/20 | 0.43 |
| ▸ | NAMPT | P43490 | 3/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | AKT2 | P31751 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | YES1 | P07947 | 1/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.31 |
| ▸ | ELOVL6 | Q9H5J4 | 1/20 | 0.31 |
| ▸ | ELOVL3 | Q9HB03 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29314840 | 0.88 | NLRP3 (0.44) | NLRP3 | |
| SCHEMBL29322560 | 0.84 | NLRP3 (0.43) | NLRP3NAMPTELOVL1ELOVL6ELOVL3 | |
| SCHEMBL27194823 | 0.79 | NLRP3 (0.49) | NLRP3NAMPTROCK2ROCK1JAK2 | |
| SCHEMBL23037647 | 0.76 | NLRP3 (0.53) | NLRP3AKT1CHEK1JAK2 | |
| SCHEMBL30539887 | 0.76 | NLRP3 (0.53) | NLRP3AKT1CHEK1JAK2 | |
| SCHEMBL29314845 | 0.74 | NLRP3 (0.52) | NLRP3AKT1ROCK2ROCK1JAK2 | |
| SCHEMBL30539937 | 0.73 | NLRP3 (0.41) | NLRP3 | |
| SCHEMBL23037648 | 0.73 | NLRP3 (0.41) | NLRP3 | |
| SCHEMBL23037706 | 0.72 | SRC (0.31) | NAMPTYES1PDGFRBSRCEPHB4 | |
| SCHEMBL29314706 | 0.72 | TLR8 (0.34) | NAMPTYES1PDGFRBSRCEPHB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037344-B2 | NLRP3 modulators | INNATE TUMOR IMMUNITY, INC (US) | 2024-07-16 | — | — | US | disclosed |
| US-12037344-B2 | NLRP3 modulators | INNATE TUMOR IMMUNITY, INC (US) | 2024-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12037344-B2 | NLRP3 modulators | NLRP3, NLRP1, PYCARD | NLRP3 1/4885NAMPT 122/4885AKT1 3066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.