Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.48 |
| ▸ | DRD4 | P21917 | 6/20 | 0.48 |
| ▸ | DRD3 | P35462 | 6/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29316476 | 1.00 | DRD2 (0.48) | DRD2DRD4DRD3L3MBTL1ALDH1A1 | |
| SCHEMBL12570290 | 0.89 | DRD2 (0.57) | DRD2DRD4DRD3L3MBTL1ALDH1A1 | |
| SCHEMBL12570286 | 0.89 | DRD2 (0.57) | DRD2DRD4DRD3L3MBTL1ALDH1A1 | |
| SCHEMBL31201179 | 0.89 | KDM4E (0.48) | L3MBTL1SLC6A4KDM4EMAPK1TDP1 | |
| SCHEMBL8675393 | 0.89 | DRD2 (0.57) | DRD2DRD4DRD3L3MBTL1ALDH1A1 | |
| SCHEMBL12570291 | 0.89 | DRD2 (0.57) | DRD2DRD4DRD3L3MBTL1ALDH1A1 | |
| SCHEMBL4239666 | 0.89 | DRD2 (0.57) | DRD2DRD4DRD3L3MBTL1ALDH1A1 | |
| SCHEMBL16183163 | 0.87 | DRD2 (0.55) | DRD2DRD4DRD3L3MBTL1HPGD | |
| SCHEMBL12570294 | 0.83 | DRD2 (0.57) | DRD2DRD4DRD3L3MBTL1ALDH1A1 | |
| SCHEMBL313373 | 0.82 | DRD2 (0.64) | DRD2DRD4DRD3L3MBTL1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238461-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | JANSSEN BIOTECH, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240238461-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | BDNF, CD47, MAG | DRD2 1013/4885DRD4 1341/4885DRD3 1058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.