Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.84 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | CA9 | Q16790 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12169334 | 0.98 | ALDH1A1 (0.87) | ALDH1A1LMNAHPGDHTTMEN1 | |
| SCHEMBL8048430 | 0.94 | ALDH1A1 (0.96) | ALDH1A1LMNAHPGDHTTMEN1 | |
| SCHEMBL9066249 | 0.94 | ALDH1A1 (0.96) | ALDH1A1LMNAHPGDHTTMEN1 | |
| SCHEMBL18894208 | 0.92 | ALDH1A1 (1.00) | ALDH1A1LMNAHPGDHTTMEN1 | |
| SCHEMBL16503455 | 0.87 | ALDH1A1 (0.84) | ALDH1A1LMNAHPGDHTTMEN1 | |
| SCHEMBL17281797 | 0.86 | ALDH1A1 (0.82) | ALDH1A1LMNAHPGDHTTMEN1 | |
| SCHEMBL26219802 | 0.86 | ALDH1A1 (0.82) | ALDH1A1LMNAHPGDHTTMEN1 | |
| SCHEMBL19593673 | 0.86 | ALDH1A1 (0.82) | ALDH1A1LMNAHPGDHTTMEN1 | |
| SCHEMBL15581459 | 0.86 | ALDH1A1 (0.62) | ALDH1A1LMNAHPGDHTTMEN1 | |
| SCHEMBL439077 | 0.84 | ALDH1A1 (0.84) | ALDH1A1LMNAHPGDHTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238461-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | JANSSEN BIOTECH, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240238461-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | BDNF, CD47, MAG | ALDH1A1 1381/4885LMNA 3701/4885HPGD 1663/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.