Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 1/20 | 0.48 |
| ▸ | VEGFA | P15692 | 1/20 | 0.46 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2930010 | 0.91 | KDM4E (0.51) | KDM4EKMT2AMEN1TP53MAPK1 | |
| SCHEMBL520517 | 0.86 | KDM4E (0.51) | KDM4EKMT2AMEN1TP53MAPK1 | |
| SCHEMBL28670217 | 0.85 | MEN1 (0.50) | KDM4EKMT2AMEN1TP53MAPK1 | |
| SCHEMBL28662739 | 0.84 | FAAH (0.49) | KDM4EKMT2AMEN1TP53MAPK1 | |
| SCHEMBL15155944 | 0.84 | KDM4E (0.49) | KDM4EKMT2AMEN1TP53MAPK1 | |
| SCHEMBL28650471 | 0.84 | VEGFA (0.49) | KDM4EKMT2AMEN1TP53MAPK1 | |
| SCHEMBL28659906 | 0.84 | KMT2A (0.49) | KDM4EKMT2AMEN1TP53MAPK1 | |
| SCHEMBL15302589 | 0.84 | KDM4E (0.51) | KDM4EKMT2AMEN1TP53MAPK1 | |
| SCHEMBL5783899 | 0.82 | KDM4E (0.47) | KDM4EKMT2AMEN1TP53MAPK1 | |
| SCHEMBL18970187 | 0.82 | ALDH1A1 (0.52) | KDM4EKMT2AMEN1TP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229377-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | Wyeth LLC (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009076602-A1 | 5-ALKYL/ALKENYL-3-CYANOPYRIDINES AS KINASE INHIBITORS | WYETH (US) | 2009-06-18 | — | — | WO | disclosed |