SCHEMBL2931707

SCHEMBL2931707

Fc1cc(F)c(F)c(Cl)c1F

nearest known ligand 0.38

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CA1 P00915 3/20 0.38
CA2 P00918 3/20 0.38
CA4 P22748 2/20 0.38
CA12 O43570 1/20 0.38
CA7 P43166 1/20 0.38
CA13 Q8N1Q1 1/20 0.38
CES2 O00748 2/20 0.35
CES1 P23141 2/20 0.35
GRIN2D O15399 1/20 0.33
GRIN3B O60391 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2A Q12879 1/20 0.33
GRIN2B Q13224 1/20 0.33
GRIN2C Q14957 1/20 0.33
GRIN3A Q8TCU5 1/20 0.33
CYP3A4 P08684 1/20 0.32
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Phosphoric Acid SCHEMBL28983529 0.84 CA1 (0.39) CA1CA2CA4CA12CA7
SCHEMBL28490907 0.82 CA1 (0.32) CA1CA2CA4CA12CA7
SCHEMBL2930354 0.80 GRIN2D (0.40) CA1CA2CA4CA12CA7
SCHEMBL28271960 0.80 GAA (0.35) CA1CA2CA12CA7CA13
SCHEMBL7576204 0.80 CA1 (0.38) CA1CA2CA4CA12CA7
SCHEMBL11707481 0.80 POLB (0.40) CYP3A4
SCHEMBL30434373 0.80 CA12 (0.31) CA1CA2CA12CA7CA13
SCHEMBL29006241 0.80 CA12 (0.31) CA1CA2CA12CA7CA13
SCHEMBL4453298 0.79 GRIN2D (0.43) CA1CA2CA4CA12CA7
SCHEMBL1756502 0.78 CYP3A4 (0.47) CES2CES1GRIN2DGRIN3BGRIN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1362860-B1 Method for producing tetrakis (fluoraryl)borate magnesium compound NIPPON CATALYTIC CHEM IND (JP) 2010-09-15 EP claimed
US-7205441-B2 Method for producing tetrakis (fluoroaryl) borate-magnesium compound NIPPON SHOKUBAI CO., LTD. (JP) 2007-04-17 US claimed
US-20030216598-A1 Method for producing tetrakis ( fluoroaryl) borate-magnesium compound NIPPON SHOKUBAI CO., LTD. (JP) 2003-11-20 US claimed
EP-1362860-A1 Method for producing tetrakis (fluoroaryl) borate magnesium compound Nippon Shokubai Co., Ltd. (JP) 2003-11-19 EP claimed
CN-118108573-A Diaryl vinyl poly-fluoro aromatic hydrocarbon derivative and synthesis method thereof 中国科学院大连化学物理研究所 2024-05-31 CN disclosed
WO-2023190846-A1 METHOD FOR PRODUCING FLUORINE-CONTAINING AROMATIC COMPOUND ダイキン工業株式会社 2023-10-05 WO disclosed
CN-115298160-A Pd-catalyzed amination of fluorinated aryl chlorides 巴斯夫欧洲公司 2022-11-04 CN disclosed
EP-1362860-B1 Method for producing tetrakis (fluoraryl)borate magnesium compound NIPPON CATALYTIC CHEM IND (JP) 2010-09-15 EP disclosed
US-7205441-B2 Method for producing tetrakis (fluoroaryl) borate-magnesium compound NIPPON SHOKUBAI CO., LTD. (JP) 2007-04-17 US disclosed
US-20030216598-A1 Method for producing tetrakis ( fluoroaryl) borate-magnesium compound NIPPON SHOKUBAI CO., LTD. (JP) 2003-11-20 US disclosed
EP-1362860-A1 Method for producing tetrakis (fluoroaryl) borate magnesium compound Nippon Shokubai Co., Ltd. (JP) 2003-11-19 EP disclosed
US-6248265-B1 Clean generation of a fluoroaryl grignard reagent ALBEMARLE CORPORATION 2001-06-19 US disclosed
EP-0163230-B2 Process for producing aromatic chlorine compounds ASAHI GLASS CO LTD (JP) 1996-03-06 EP disclosed
US-5213710-A Benzene derivatives and a liquid-crystalline medium MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1993-05-25 US disclosed
EP-0163230-B1 PROCESS FOR PRODUCING AROMATIC CHLORINE COMPOUNDS ASAHI GLASS COMPANY LTD. (JP) 1989-03-29 EP disclosed
EP-0163230-A2 Process for producing aromatic chlorine compounds ASAHI GLASS COMPANY LTD. (JP) 1985-12-04 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030216598-A1 Method for producing tetrakis ( fluoroaryl) borate-magnesium compound KRAS, MGAM, CA3 CA1 190/4885CA2 119/4885CA4 257/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.