Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CRHR1 | P34998 | 10/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2497119 | 0.91 | HPGD (0.35) | HPGDPOLBMEN1KMT2AALOX15 | |
| SCHEMBL2493424 | 0.91 | HPGD (0.34) | HPGDPOLBMEN1KMT2AALOX15 | |
| SCHEMBL2494028 | 0.86 | HPGD (0.35) | HPGDPOLBMEN1KMT2AALOX15 | |
| SCHEMBL2495431 | 0.84 | HPGD (0.33) | HPGDPOLBKDM4EALDH1A1MAPT | |
| SCHEMBL22335453 | 0.84 | HPGD (0.34) | HPGDPOLBMEN1KMT2AKDM4E | |
| SCHEMBL545488 | 0.83 | MEN1 (0.37) | HPGDPOLBMEN1KMT2AALOX15 | |
| SCHEMBL2931270 | 0.80 | HPGD (0.39) | HPGDPOLBMEN1KMT2AALOX15 | |
| SCHEMBL2495097 | 0.78 | CRHR1 (0.35) | HPGDPOLBKDM4EALDH1A1MAPT | |
| SCHEMBL22958812 | 0.77 | HPGD (0.35) | HPGDPOLBMEN1KMT2AALOX15 | |
| SCHEMBL2930712 | 0.77 | CRHR1 (0.39) | HPGDPOLBMEN1KMT2AALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094709-B1 | THIAZOLE PYRAZOLOPYRIMIDINES AS CRF1 RECEPTOR ANTAGONISTS | LILLY CO ELI (US) | 2010-09-15 | — | — | EP | disclosed |