Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.33 |
| ▸ | AKT1 | P31749 | 2/20 | 0.33 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30217625 | 0.82 | MAP4K1 (0.46) | MAP4K1TRPA1IRAK4CYP1A2CYP2D6 | |
| SCHEMBL25088414 | 0.82 | MAP4K1 (0.46) | MAP4K1TRPA1IRAK4CYP1A2CYP2D6 | |
| SCHEMBL1935022 | 0.81 | MAP4K1 (0.45) | MAP4K1TRPA1IRAK4CYP1A2CYP2D6 | |
| SCHEMBL2600506 | 0.80 | AXL (0.50) | AXLPRKCITRPA1IRAK4ROCK2 | |
| SCHEMBL20758322 | 0.76 | CHEK1 (0.51) | AXLPRKCITRPA1ROCK2ROCK1 | |
| SCHEMBL20758384 | 0.73 | AXL (0.41) | MAP4K1AXLPRKCIROCK2ROCK1 | |
| SCHEMBL4780230 | 0.72 | CHEK1 (0.56) | MAP4K1TRPA1IRAK4CYP1A2CYP2D6 | |
| SCHEMBL12146877 | 0.72 | HTR2A (0.43) | MAP4K1TRPA1IRAK4CYP1A2CYP2D6 | |
| SCHEMBL16022948 | 0.71 | MAP4K1 (0.38) | MAP4K1TRPA1IRAK4CYP1A2CYP2D6 | |
| SCHEMBL2693766 | 0.71 | LRRK2 (0.53) | MAP4K1AXLPRKCITRPA1IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239794-A1 | PKC-Theta Modulators | EXSCIENTIA AI LIMITED (GB) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239794-A1 | PKC-Theta Modulators | PRKCQ, PRKCH, PRKCZ | MAP4K1 185/4885AXL 4666/4885PRKCI 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.