SCHEMBL30217625

SCHEMBL30217625

CCc1c[nH]c2ncc(Br)c(Cl)c12

nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MAP4K1 Q92918 5/20 0.46
TRPA1 O75762 1/20 0.36
IRAK4 Q9NWZ3 1/20 0.36
CYP1A2 P05177 1/20 0.35
CYP2D6 P10635 1/20 0.35
CYP3A4 P08684 2/20 0.34
PDPK1 O15530 1/20 0.33
AKT1 P31749 2/20 0.33
ABL1 P00519 1/20 0.31
PRMT5 O14744 1/20 0.30
WDR77 Q9BQA1 1/20 0.30
LRRK2 Q5S007 1/20 0.30
CHEK1 O14757 1/20 0.30
JAK3 P52333 1/20 0.30
MAPK1 P28482 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25088414 1.00 MAP4K1 (0.46) MAP4K1TRPA1IRAK4CYP1A2CYP2D6
SCHEMBL29317874 0.82 MAP4K1 (0.46) MAP4K1TRPA1IRAK4CYP1A2CYP2D6
SCHEMBL30217562 0.80 MAP4K1 (0.32) MAP4K1
SCHEMBL25088065 0.80 MAP4K1 (0.32) MAP4K1
SCHEMBL1935022 0.79 MAP4K1 (0.45) MAP4K1TRPA1IRAK4CYP1A2CYP2D6
SCHEMBL21954726 0.78 LRRK2 (0.38) TRPA1AKT1LRRK2CHEK1MAPK1
SCHEMBL15359645 0.75 CHEK1 (0.36) MAP4K1PDPK1LRRK2CHEK1MAPK1
SCHEMBL2112465 0.75 CHEK1 (0.51) TRPA1IRAK4LRRK2CHEK1JAK3
SCHEMBL30689578 0.74 MAP4K1 (0.31) MAP4K1
SCHEMBL31318237 0.74 CYP2A6 (0.45) LRRK2CHEK1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250368640-A1 MULTIPLE KINASE DEGRADERS, COMPOSITIONS COMPRISING THE DEGRADER, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2025-12-04 US disclosed
EP-4598918-A1 GSPT1 DEGRADERS, COMPOSITIONS COMPRISING THE DEGRADER, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2025-08-13 EP disclosed
EP-4540247-A1 MULTI-KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2025-04-23 EP disclosed
EP-4540246-A1 MULTIPLE KINASE DEGRADERS, COMPOSITIONS COMPRISING THE DEGRADER, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2025-04-23 EP disclosed
CN-119137123-A Multi-kinase degradants, compositions comprising the same, and methods of use thereof 百放开曼有限公司 2024-12-13 CN disclosed
CN-119032093-A Multi-kinase inhibitors, compositions and methods of use 百放开曼有限公司 2024-11-26 CN disclosed
EP-4392420-A1 HPK1 DEGRADERS, COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2024-07-03 EP disclosed
EP-4392417-A1 KINASE MODULATORS, COMPOSITIONS COMPRISING THE KINASE MODULATOR, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2024-07-03 EP disclosed
WO-2024073871-A1 GSPT1 DEGRADERS, COMPOSITIONS COMPRISING THE DEGRADER, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2024-04-11 WO disclosed
CN-117858874-A HPK1 degrading agents, compositions comprising the same, and methods of use thereof 百放开曼有限公司 2024-04-09 CN disclosed
WO-2023246490-A1 MULTIPLE KINASE DEGRADERS, COMPOSITIONS COMPRISING THE DEGRADER, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2023-12-28 WO disclosed
WO-2023246491-A1 MULTI-KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2023-12-28 WO disclosed
WO-2023245327-A1 MULTIPLE KINASE DEGRADERS, COMPOSITIONS COMPRISING THE DEGRADER, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2023-12-28 WO disclosed
WO-2023245329-A1 MULTI-KINASE INHIBITORS, COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME BIOFRONT LTD (KY) 2023-12-28 WO disclosed
WO-2023025091-A1 HPK1 DEGRADERS, COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME BIOFRONT LTD (CAYMAN) (KY) 2023-03-02 WO disclosed
WO-2023023941-A1 HPK1 DEGRADERS, COMPOSITIONS COMPRISING THE HPKI DEGRADER, AND METHODS OF USING THE SAME BIOFRONT LTD (CAYMAN) (KY) 2023-03-02 WO disclosed
WO-2023025092-A1 KINASE MODULATORS, COMPOSITIONS COMPRISING THE KINASE MODULATOR, AND METHODS OF USING THE SAME BIOFRONT LTD (CAYMAN) (KY) 2023-03-02 WO disclosed
WO-2023023942-A1 HPK1 INHIBITORS, COMPOSITIONS COMPRISING HPK1 INHIBITOR, AND METHODS OF USING THE SAME BIOFRONT LTD (CAYMAN) (KY) 2023-03-02 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250368640-A1 MULTIPLE KINASE DEGRADERS, COMPOSITIONS COMPRISING THE DEGRADER, AND METHODS OF USING THE SAME MAP4K1, MAP4K4, MAP4K5 MAP4K1 1/4885TRPA1 4749/4885IRAK4 279/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.