SCHEMBL29317976

SCHEMBL29317976

COC(=O)c1ccc(C2CCN(CC3=C(c4ccc(Cl)cc4)CCC(C)(C)C3)CC2)cc1

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
BCL2L1 Q07817 9/20 0.59
BCL2 P10415 10/20 0.56
MCHR1 Q99705 1/20 0.41
KDM1A O60341 2/20 0.41
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
HPGD P15428 1/20 0.40
CXCR3 P49682 1/20 0.40
KDM4E B2RXH2 1/20 0.40
CHRM4 P08173 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29404799 0.84 MCHR1 (0.42) BCL2L1BCL2MCHR1KDM1AGAA
SCHEMBL21751667 0.80 BCL2L1 (0.59) BCL2L1BCL2MAPT
SCHEMBL26648157 0.78 BCL2L1 (0.69) BCL2L1BCL2MAPT
SCHEMBL5131886 0.75 BCL2L1 (0.53) BCL2L1BCL2
SCHEMBL1497713 0.75 BCL2L1 (0.64) BCL2L1BCL2
SCHEMBL12054428 0.74 BCL2L1 (0.85) BCL2L1BCL2
SCHEMBL1567421 0.74 BCL2L1 (1.00) BCL2L1BCL2
SCHEMBL30857664 0.74 BCL2L1 (0.50) BCL2L1BCL2GAAMAPTHPGD
SCHEMBL30857713 0.74 BCL2L1 (0.50) BCL2L1BCL2
SCHEMBL30857518 0.74 BCL2L1 (0.50) BCL2L1BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4397661-A1 COMPOUND FOR DEGRADATION OF BCL-2 FAMILY PROTEINS AND MEDICAL APPLICATION THEREOF Xizang Haisco Pharmaceutical Co., Ltd. (CN) 2024-07-10 EP disclosed