Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.33 |
| ▸ | PDE8B | O95263 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29302469 | 0.83 | PDE8B (0.35) | KDM4EHSD17B10HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL23139774 | 0.83 | DRD2 (0.36) | KDM4EHSD17B10HPGDTP53METTL3 | |
| SCHEMBL24738088 | 0.81 | KDM4E (0.34) | KDM4EHSD17B10HPGDALDH1A1TP53 | |
| SCHEMBL24738135 | 0.76 | CCNA2 (0.33) | KDM4ETP53METTL3KLKB1 | |
| SCHEMBL24737887 | 0.76 | METTL3 (0.32) | KDM4ETP53METTL3KLKB1 | |
| SCHEMBL27030315 | 0.74 | KDM4E (0.60) | KDM4ETP53METTL3KLKB1 | |
| SCHEMBL27029949 | 0.74 | KLKB1 (0.39) | KDM4EHSD17B10HPGDALDH1A1TP53 | |
| SCHEMBL29302747 | 0.73 | KDM4E (0.38) | KDM4EALDH1A1TP53SMN1; SMN2METTL3 | |
| Hydrochloric Acid SCHEMBL27030313 | 0.73 | KDM4E (0.58) | KDM4ETP53METTL3KLKB1 | |
| SCHEMBL29302529 | 0.73 | METTL3 (0.30) | METTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4031547-B1 | PLASMA KALLIKREIN INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-17 | — | — | EP | disclosed |