Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 7/20 | 0.48 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.46 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | NCF1 | P14598 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29322740 | 0.90 | NLRP3 (0.47) | NLRP3TLR8TLR7JAK2CYP1A2 | |
| SCHEMBL29322759 | 0.89 | TLR8 (0.53) | NLRP3TLR8TLR7JAK2CYP1A2 | |
| SCHEMBL29322746 | 0.88 | TLR8 (0.60) | NLRP3TLR8TLR7JAK2CYP1A2 | |
| SCHEMBL29322768 | 0.87 | NLRP3 (0.53) | NLRP3TLR8TLR7JAK2CYP1A2 | |
| SCHEMBL29322799 | 0.86 | NLRP3 (0.48) | NLRP3TLR8TLR7JAK2NPC1 | |
| SCHEMBL29315292 | 0.83 | NLRP3 (0.49) | NLRP3TLR8TLR7JAK2NPC1 | |
| SCHEMBL29322778 | 0.82 | NLRP3 (0.47) | NLRP3TLR8TLR7JAK2AKT1 | |
| SCHEMBL29325663 | 0.80 | NLRP3 (0.47) | NLRP3TLR8TLR7JAK2NPC1 | |
| SCHEMBL29325656 | 0.80 | NLRP3 (0.49) | NLRP3TLR8TLR7JAK2 | |
| SCHEMBL29322795 | 0.80 | NLRP3 (0.46) | NLRP3TLR8TLR7JAK2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037344-B2 | NLRP3 modulators | INNATE TUMOR IMMUNITY, INC (US) | 2024-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12037344-B2 | NLRP3 modulators | NLRP3, NLRP1, PYCARD | NLRP3 1/4885TLR8 210/4885TLR7 236/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.