Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 8/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 8/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 1.00 |
| ▸ | MAPT | P10636 | 5/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 1/20 | 1.00 |
| ▸ | NTSR1 | P30989 | 1/20 | 1.00 |
| ▸ | CRHBP | P24387 | 2/20 | 0.60 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | METAP1 | P53582 | 2/20 | 0.58 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.57 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.57 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.57 |
| ▸ | RET | P07949 | 1/20 | 0.57 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10095181 | 0.88 | MEN1 (0.78) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL14281294 | 0.84 | MEN1 (0.71) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL4037782 | 0.83 | METAP1 (0.76) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL8022041 | 0.82 | MAPK1 (0.70) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL14306896 | 0.82 | MEN1 (0.68) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL10134156 | 0.80 | SIRT2 (0.69) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL14680296 | 0.79 | KMT2A (0.64) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL16712246 | 0.77 | MAPK1 (0.63) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL6001142 | 0.77 | PDGFRB (0.73) | MEN1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL10095183 | 0.76 | METAP1 (0.65) | MEN1KMT2AALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238264-A1 | INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF | DISARM THERAPEUTICS, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240238264-A1 | INHIBITORS OF SARM1 NADASE ACTIVITY AND USES THEREOF | SARM1, NADK, NNMT | MEN1 3371/4885KMT2A 2098/4885ALDH1A1 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.