Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.41 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.39 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | CDK2 | P24941 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16205502 | 0.82 | GABRG2 (0.41) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL21920779 | 0.78 | PIK3CD (0.44) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL19255201 | 0.77 | NR1H2 (0.52) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL32673595 | 0.76 | CDK2 (0.44) | GABRG2GABRB3GABRA5GABRA1GABRA2 | |
| SCHEMBL12685167 | 0.74 | NR1H2 (0.43) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL16608284 | 0.74 | GABRG2 (0.38) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL21919931 | 0.74 | GPR119 (0.40) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL6508596 | 0.74 | NR1H2 (0.39) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL12685162 | 0.74 | NR1H2 (0.39) | GPR119GABRG2GABRB3GABRA5GABRA1 | |
| SCHEMBL23459080 | 0.73 | GPR119 (0.37) | GPR119GABRG2GABRB3GABRA5GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4031547-B1 | PLASMA KALLIKREIN INHIBITORS AND USES THEREOF | TAKEDA PHARMACEUTICALS CO (JP) | 2024-07-17 | — | — | EP | disclosed |