Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA5 | P31644 | 20/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2926911 | 0.91 | GABRA5 (0.70) | GABRA5 | |
| SCHEMBL2929451 | 0.86 | GABRA5 (0.70) | GABRA5 | |
| SCHEMBL4159064 | 0.82 | GABRA5 (1.00) | GABRA5 | |
| SCHEMBL4155856 | 0.81 | GABRA5 (1.00) | GABRA5 | |
| SCHEMBL4155478 | 0.81 | GABRA5 (1.00) | GABRA5 | |
| SCHEMBL2923151 | 0.80 | GABRA5 (0.78) | GABRA5 | |
| SCHEMBL2921983 | 0.79 | GABRA1 (0.58) | GABRA5 | |
| SCHEMBL2927274 | 0.78 | GABRA5 (0.54) | GABRA5 | |
| SCHEMBL2921991 | 0.78 | GABRA1 (0.58) | GABRA5 | |
| SCHEMBL535936 | 0.77 | GABRA5 (0.72) | GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227467-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-09-15 | — | — | EP | disclosed |
| WO-2009071476-A1 | ISOXAZOLO-PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-11 | — | — | WO | disclosed |