Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29323908 | 0.91 | GNAO1 (0.38) | CYP2D6KDM1AHRH3SLC6A4SLC6A3 | |
| SCHEMBL26744954 | 0.89 | HRH3 (0.39) | CYP2D6KDM1AHRH3SLC6A4SLC6A3 | |
| SCHEMBL26743216 | 0.89 | HRH3 (0.45) | CYP2D6KDM1AHRH3SLC6A4SLC6A3 | |
| SCHEMBL25492962 | 0.89 | NCF1 (0.41) | KDM1AHRH3GNAO1 | |
| SCHEMBL26706166 | 0.88 | CYP2D6 (0.36) | CYP2D6KDM1AHRH3SLC6A4SLC6A3 | |
| SCHEMBL26747096 | 0.88 | HRH3 (0.39) | CYP2D6KDM1AHRH3SLC6A4SLC6A3 | |
| SCHEMBL29329947 | 0.84 | SLC6A4 (0.40) | KDM1AHRH3SLC6A4SLC6A3GNAO1 | |
| SCHEMBL26741830 | 0.84 | HRH3 (0.48) | KDM1AHRH3GNAO1 | |
| SCHEMBL26744662 | 0.84 | NPY1R (0.37) | CYP2D6KDM1AHRH3SLC6A4SLC6A3 | |
| SCHEMBL29342462 | 0.83 | HRH3 (0.41) | CYP2D6KDM1AHRH3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240238423-A9 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | Treeline Biosciences, Inc. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240238423-A9 | TETRAHYDROISOQUINOLINE HETEROBIFUNCTIONAL BCL-XL DEGRADERS | BCL2A1, BCL2L1, BCL3 | CYP2D6 1324/4885KDM1A 1195/4885HRH3 4026/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.