Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.53 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.53 |
| ▸ | FASN | P49327 | 9/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29326606 | 0.91 | KDM4E (0.44) | GRIA1CACNG8FASNKDM4EHTT | |
| SCHEMBL27378401 | 0.90 | GRIA1 (0.48) | GRIA1CACNG8FASNKDM4EHTT | |
| SCHEMBL29326437 | 0.90 | KDM4E (0.50) | GRIA1CACNG8KDM4EHTTNPEPPS | |
| SCHEMBL29326439 | 0.88 | NPEPPS (0.41) | GRIA1CACNG8FASNKDM4EHTT | |
| SCHEMBL29326335 | 0.87 | NPEPPS (0.43) | FASNKDM4EHTTNPEPPSGAA | |
| SCHEMBL29326358 | 0.86 | HSD17B10 (0.45) | GRIA1CACNG8FASNKDM4ENPEPPS | |
| SCHEMBL29326678 | 0.85 | FASN (0.40) | GRIA1CACNG8FASNKDM4EHTT | |
| SCHEMBL29326611 | 0.85 | PTGES (0.48) | GRIA1CACNG8KDM4EHTTNPEPPS | |
| SCHEMBL29326451 | 0.84 | KDM4E (0.45) | KDM4EHTTNPEPPSGAATP53 | |
| SCHEMBL29326444 | 0.83 | TP53 (0.44) | GRIA1CACNG8KDM4EHTTNPEPPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | ACE2, TMPRSS2, ACE | GRIA1 3704/4885CACNG8 3522/4885FASN 1084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.