Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 2/20 | 0.40 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27379062 | 0.90 | METAP2 (0.38) | NPEPPSMETAP2AURKAHAVCR2MAPK13 | |
| SCHEMBL29326614 | 0.88 | KDM4E (0.45) | ITGA4ITGB7NPEPPSTDP1ALDH1A1 | |
| SCHEMBL29326616 | 0.84 | IDO1 (0.44) | HCAR1ITGA4ITGB7NPEPPSTDP1 | |
| SCHEMBL29326236 | 0.81 | NPEPPS (0.44) | HCAR1ITGA4ITGB7NPEPPSPDE7A | |
| SCHEMBL29326278 | 0.80 | AURKA (0.40) | HCAR1ITGA4ITGB7NPEPPSAURKA | |
| SCHEMBL27192007 | 0.79 | KDM4E (0.42) | NPEPPSALDH1A1KDM4EHTT | |
| SCHEMBL29326183 | 0.77 | ERCC5 (0.43) | HCAR1ITGA4ITGB7NPEPPSAURKA | |
| SCHEMBL29326225 | 0.76 | NPEPPS (0.48) | HCAR1NPEPPSAURKATDP1LMNA | |
| SCHEMBL29326391 | 0.75 | KDM4E (0.45) | HCAR1ITGA4ITGB7NPEPPSHAVCR2 | |
| SCHEMBL29326440 | 0.75 | NPEPPS (0.43) | HCAR1ITGA4ITGB7NPEPPSTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | ACE2, TMPRSS2, ACE | HCAR1 4317/4885ITGA4 4792/4885ITGB7 4641/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.