Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FEN1 | P39748 | 1/20 | 0.53 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.41 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MIF | P14174 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27377852 | 0.92 | NPEPPS (0.44) | FEN1NPEPPSKDM4EHTTHSD17B10 | |
| SCHEMBL27377729 | 0.91 | PTGES (0.46) | FEN1NPEPPSKDM4EHTTPTGES | |
| SCHEMBL27377871 | 0.90 | KDM4E (0.50) | FEN1NPEPPSKDM4EHTTPTGES | |
| SCHEMBL27377727 | 0.90 | CYP11B1 (0.48) | FEN1NPEPPSKDM4EHTTCYP11B1 | |
| SCHEMBL27377715 | 0.89 | FEN1 (0.42) | FEN1NPEPPSKDM4EHTTTNKS2 | |
| SCHEMBL27377863 | 0.89 | KDM4E (0.46) | FEN1NPEPPSKDM4EHTTHSD17B10 | |
| SCHEMBL27377600 | 0.88 | NPEPPS (0.43) | FEN1NPEPPSKDM4EHTTHSD17B10 | |
| SCHEMBL27377713 | 0.88 | FEN1 (0.41) | FEN1NPEPPSKDM4EHTTHSD17B10 | |
| SCHEMBL29328540 | 0.86 | NPEPPS (0.44) | FEN1NPEPPSKDM4EHTTTNKS2 | |
| SCHEMBL27377718 | 0.86 | NPEPPS (0.41) | FEN1NPEPPSKDM4EHTTTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | GILEAD SCIENCES, INC. | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239807-A1 | SARS-COV2 MAIN PROTEASE INHIBITORS | ACE2, TMPRSS2, ACE | FEN1 1012/4885NPEPPS 168/4885KDM4E 3744/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.