Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 2/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24835755 | 0.93 | HDAC1 (0.44) | HDAC1HDAC6NPC1NR1H2NR1H3 | |
| SCHEMBL1653727 | 0.86 | NPC1 (0.52) | HDAC1HDAC6NPC1NR1H2NR1H3 | |
| SCHEMBL29514535 | 0.85 | PARP1 (0.39) | NPC1NR1H2NR1H3USP30PARP1 | |
| SCHEMBL5458875 | 0.85 | NPC1 (0.48) | HDAC1HDAC6NPC1NR1H2NR1H3 | |
| SCHEMBL16466085 | 0.82 | OPRD1 (0.44) | NPC1DPP4HTTRAB9ASMN1; SMN2 | |
| SCHEMBL31056656 | 0.81 | NR1H2 (0.46) | HDAC1HDAC6NPC1NR1H2NR1H3 | |
| SCHEMBL14833043 | 0.80 | NPC1 (0.42) | HDAC1HDAC6NPC1NR1H2NR1H3 | |
| SCHEMBL29390268 | 0.80 | NR1H2 (0.45) | HDAC1HDAC6NR1H2NR1H3PARP1 | |
| SCHEMBL30736727 | 0.80 | NR1H2 (0.47) | HDAC1HDAC6NPC1NR1H2NR1H3 | |
| SCHEMBL12988407 | 0.79 | NR1H2 (0.50) | HDAC1HDAC6NR1H2NR1H3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024148274-A1 | COMPLEMENT INHIBITION | APELLIS PHARMACEUTICALS, INC. (US) | 2024-07-11 | — | — | WO | disclosed |
| WO-2024148274-A1 | COMPLEMENT INHIBITION | APELLIS PHARMACEUTICALS, INC. (US) | 2024-07-11 | — | — | WO | disclosed |