Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26115692 | 0.93 | PARP1 (0.43) | PARP1PRMT5WDR77ALDH1A1RIPK1 | |
| SCHEMBL29328639 | 0.85 | HDAC1 (0.43) | PARP1ALDH1A1RIPK1NR1H2NR1H3 | |
| SCHEMBL3261075 | 0.84 | PRMT5 (0.53) | PRMT5WDR77ALDH1A1RIPK1GPR119 | |
| SCHEMBL29514552 | 0.81 | RIPK1 (0.48) | PRMT5WDR77ALDH1A1RIPK1GPR119 | |
| SCHEMBL5229321 | 0.81 | GPR119 (0.43) | PARP1PRMT5WDR77ALDH1A1RIPK1 | |
| SCHEMBL22285173 | 0.80 | NR1H2 (0.49) | PARP1RIPK1GPR119NR1H2NR1H3 | |
| SCHEMBL874416 | 0.80 | NR1H2 (0.49) | PARP1RIPK1GPR119NR1H2NR1H3 | |
| SCHEMBL4325057 | 0.80 | NR1H2 (0.49) | PARP1RIPK1GPR119NR1H2NR1H3 | |
| SCHEMBL28371859 | 0.79 | GPR119 (0.46) | ALDH1A1RIPK1GPR119LMNA | |
| SCHEMBL29546006 | 0.79 | GPR119 (0.46) | ALDH1A1RIPK1GPR119LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114181205-A | Pyrazolopyridine compound or salt thereof, and preparation method and application thereof | 上海辉启生物医药科技有限公司 | 2022-03-15 | — | — | CN | disclosed |