SCHEMBL29329365

SCHEMBL29329365

N#Cc1cc(OCCc2ccc(F)cc2)cc(Nc2ccc3cc[nH]c3c2)n1

nearest known ligand 0.40

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
MET P08581 1/20 0.40
SYK P43405 3/20 0.40
ESR1 P03372 3/20 0.39
CNR2 P34972 1/20 0.38
PRKCQ Q04759 6/20 0.37
PRKCD Q05655 1/20 0.37
CDK1 P06493 1/20 0.36
KDR P35968 1/20 0.36
AHR P35869 1/20 0.36
JAK2 O60674 1/20 0.35
JAK1 P23458 1/20 0.35
MAOB P27338 1/20 0.35
APP P05067 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29329726 0.93 SYK (0.39) METSYKESR1CNR2PRKCQ
SCHEMBL29329290 0.91 PRKCQ (0.42) METSYKESR1PRKCQPRKCD
SCHEMBL29328881 0.89 SYK (0.38) METSYKPRKCQPRKCDCDK1
SCHEMBL29329785 0.89 SYK (0.39) METSYKESR1PRKCQPRKCD
SCHEMBL29329867 0.87 PRKCQ (0.40) SYKESR1PRKCQPRKCDCDK1
SCHEMBL29330342 0.87 SYK (0.40) METSYKESR1PRKCQPRKCD
SCHEMBL29329866 0.87 PRKCQ (0.38) METSYKPRKCQPRKCDCDK1
SCHEMBL29330255 0.87 ESR1 (0.42) METSYKESR1PRKCQCDK1
SCHEMBL29330563 0.86 PRKCQ (0.39) METSYKESR1PRKCQPRKCD
SCHEMBL29330433 0.85 SYK (0.41) METSYKESR1PRKCQPRKCD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151919-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2024-07-18 WO disclosed