SCHEMBL29330163

SCHEMBL29330163

N#Cc1cc(Oc2ccc(Cl)cc2)cc(Nc2ccc3cc[nH]c3c2)n1

nearest known ligand 0.42

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 3/20 0.42
SCN9A Q15858 7/20 0.41
CMA1 P23946 1/20 0.40
AHR P35869 1/20 0.40
TTBK1 Q5TCY1 2/20 0.39
TTBK2 Q6IQ55 2/20 0.39
PRKCQ Q04759 2/20 0.38
KCNH2 Q12809 3/20 0.38
SCN5A Q14524 2/20 0.38
LMNA P02545 1/20 0.37
ADRB2 P07550 1/20 0.37
MAPT P10636 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37
SYK P43405 2/20 0.36
RHEB Q15382 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29330161 0.90 ESR1 (0.48) ESR1SCN9ATTBK1TTBK2PRKCQ
SCHEMBL29330567 0.90 PRKCQ (0.45) ESR1SCN9ATTBK1TTBK2PRKCQ
SCHEMBL29329217 0.89 TTBK1 (0.41) ESR1TTBK1TTBK2PRKCQKCNH2
SCHEMBL29330425 0.89 ESR1 (0.42) ESR1SCN9ATTBK1TTBK2PRKCQ
SCHEMBL29330255 0.89 ESR1 (0.42) ESR1SCN9AAHRTTBK1TTBK2
SCHEMBL29328749 0.89 EGFR (0.42) ESR1CMA1AHRPRKCQRHEB
SCHEMBL29330164 0.89 SYK (0.40) ESR1SCN9ACMA1AHRTTBK1
SCHEMBL29330254 0.87 SYK (0.42) ESR1PRKCQSYK
SCHEMBL29330251 0.87 SYK (0.41) ESR1AHRPRKCQSYK
SCHEMBL29330248 0.86 ESR1 (0.46) ESR1SCN9ATTBK1TTBK2PRKCQ

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024151919-A1 COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH STING ACTIVITY IFM DUE, INC. (US) 2024-07-18 WO disclosed