Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 8/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.48 |
| ▸ | PNP | P00491 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL293325 | 1.00 | AHCY (0.57) | AHCYLMNATP53ADORA3ADORA2A | |
| SCHEMBL1841287 | 1.00 | AHCY (0.57) | AHCYLMNATP53ADORA3ADORA2A | |
| SCHEMBL243600 | 1.00 | AHCY (0.57) | AHCYLMNATP53ADORA3ADORA2A | |
| Trifluoroacetic Acid SCHEMBL1412146 | 0.90 | AHCY (0.48) | AHCYLMNATP53ADORA3ADORA2A | |
| Trifluoroacetic Acid SCHEMBL241441 | 0.90 | AHCY (0.48) | AHCYLMNATP53ADORA3ADORA2A | |
| SCHEMBL26381988 | 0.86 | AHCY (0.57) | AHCYLMNATP53ADORA3ADORA2A | |
| SCHEMBL13211900 | 0.86 | AHCY (0.54) | AHCYADORA3ADORA2AADORA1 | |
| SCHEMBL12050237 | 0.84 | AHCY (0.56) | AHCYLMNATP53ADORA3ADORA2A | |
| SCHEMBL8960194 | 0.84 | AHCY (0.56) | AHCYLMNATP53ADORA3ADORA2A | |
| SCHEMBL3007619 | 0.83 | LMNA (0.46) | AHCYLMNATP53ADORA3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013211-B1 | PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS | NOVARTIS AG (CH) | 2012-03-14 | — | — | EP | disclosed |