Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 9/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2928533 | 1.00 | CHEK1 (0.42) | CHEK1LRRK2IKBKBJAK2MEN1 | |
| SCHEMBL2933488 | 0.90 | CHEK1 (0.45) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL1928818 | 0.85 | IKBKB (0.55) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL1928820 | 0.85 | IKBKB (0.55) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL1928275 | 0.85 | IKBKB (0.55) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2927139 | 0.80 | CHEK1 (0.41) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL2934362 | 0.80 | CHEK1 (0.58) | CHEK1IKBKBJAK2MEN1KMT2A | |
| SCHEMBL2931062 | 0.77 | CHEK1 (0.59) | CHEK1IKBKBJAK2JAK3 | |
| SCHEMBL2932975 | 0.77 | PTGER1 (0.43) | CHEK1JAK2MEN1KMT2AMAPT | |
| SCHEMBL2933735 | 0.76 | CHEK1 (0.44) | CHEK1JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | claimed |