Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 5/20 | 0.44 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 4/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | MOK | Q9UQ07 | 3/20 | 0.39 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2928252 | 0.89 | CHEK1 (0.42) | CHEK1CYP2A13JAK2JAK3KCNH2 | |
| SCHEMBL2934362 | 0.88 | CHEK1 (0.58) | CHEK1JAK2JAK3KCNH2MAP3K7 | |
| SCHEMBL1926830 | 0.86 | CHEK1 (0.61) | CHEK1CYP2A13JAK2JAK3JAK1 | |
| SCHEMBL2931062 | 0.84 | CHEK1 (0.59) | CHEK1JAK2JAK3KCNH2MAP3K7 | |
| SCHEMBL2932975 | 0.83 | PTGER1 (0.43) | CHEK1JAK2JAK3KCNH2SCN9A | |
| SCHEMBL2932197 | 0.83 | CHEK1 (0.48) | CHEK1JAK2JAK3JAK1KCNH2 | |
| SCHEMBL5243288 | 0.83 | CHEK1 (0.41) | CHEK1JAK2JAK3KCNH2 | |
| SCHEMBL2925535 | 0.82 | JAK2 (0.43) | CHEK1JAK2JAK3KCNH2 | |
| SCHEMBL2930060 | 0.78 | CHEK1 (0.70) | CHEK1JAK2MAP3K7 | |
| SCHEMBL2933445 | 0.77 | CHEK1 (0.72) | CHEK1MAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421074-B1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2010-09-29 | — | — | EP | claimed |