Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 15/20 | 0.51 |
| ▸ | SRC | P12931 | 15/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 14/20 | 0.51 |
| ▸ | BRAF | P15056 | 7/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2929800 | 0.85 | HCK (0.49) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL3758491 | 0.84 | HCK (0.53) | HCKSRCMAPK14MAPK12BRAF | |
| Hydrochloric Acid SCHEMBL29396562 | 0.84 | HCK (0.48) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL2933845 | 0.82 | HCK (0.65) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL20382933 | 0.80 | HCK (0.47) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL23070949 | 0.79 | BRAF (0.53) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL2928498 | 0.79 | BRAF (0.58) | BRAF | |
| SCHEMBL3758499 | 0.77 | HCK (0.62) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL12790146 | 0.75 | BRAF (0.45) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL9909763 | 0.75 | BRAF (0.53) | HCKSRCMAPK14MAPK12BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |