Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCK | P08631 | 16/20 | 0.65 |
| ▸ | SRC | P12931 | 16/20 | 0.65 |
| ▸ | MAPK14 | Q16539 | 16/20 | 0.65 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.65 |
| ▸ | BRAF | P15056 | 7/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3758499 | 0.86 | HCK (0.62) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL9995012 | 0.85 | HCK (0.59) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL2931611 | 0.84 | BRAF (0.66) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL28691605 | 0.83 | BRAF (0.50) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL2928589 | 0.83 | BRAF (0.68) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL2933460 | 0.82 | HCK (0.51) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL2929840 | 0.82 | BRAF (0.67) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL4464984 | 0.81 | BRAF (0.67) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL2929800 | 0.81 | HCK (0.49) | HCKSRCMAPK14MAPK12BRAF | |
| SCHEMBL20386664 | 0.81 | SRC (0.80) | HCKSRCMAPK14MAPK12BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10100053-B2 | Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-b]pyrazin-3-one derivatives | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2018-10-16 | — | — | US | disclosed |
| EP-3074395-B1 | PROCESS FOR THE PREPARATION OF 8-(4-AMINOPHENOXY)-4H-PYRIDO[2,3-B]PYRAZIN-3-ONE DERIVATIVES | CANCER RESEARCH TECH LTD (GB) | 2018-08-22 | — | — | EP | disclosed |
| US-9708317-B2 | Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-B]pyrazin-3-one derivatives | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2017-07-18 | — | — | US | disclosed |
| US-20160297814-A1 | PROCESS FOR THE PREPARATION OF 8-(4-AMINOPHENOXY)-4H-PYRIDO[2,3-B]PYRAZIN-3-ONE DERIVATIVES | OXY SCIENTIFIC LIMITED (GB) | 2016-10-13 | — | — | US | disclosed |
| EP-2229391-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | Cancer Research Technology Limited (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009077766-A1 | PYRIDO[2,3-B]PYRAZINE-8-SUBSTITUTED COMPOUNDS AND THEIR USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10100053-B2 | Process for the preparation of 8-(4-aminophenoxy)-4H-pyrido[2,3-b]pyrazin-3-one derivatives | PAM, PDXK, GRHPR | HCK 3897/4885SRC 1622/4885MAPK14 2529/4885 |
| US-20160297814-A1 | PROCESS FOR THE PREPARATION OF 8-(4-AMINOPHENOXY)-4H-PYRIDO[2,3-B]PYRAZIN-3-ONE DERIVATIVES | PAM, PDXK, GRHPR | HCK 3897/4885SRC 1622/4885MAPK14 2529/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.