Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | CYP2A13 | Q16696 | 6/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29336273 | 0.82 | MAPT (0.49) | HTR1AHTR1DHTR1BDRD2DRD4 | |
| SCHEMBL2491351 | 0.77 | CYP2A13 (0.49) | CYP2A13CXCR4HPGDCYP2C9ALOX15 | |
| SCHEMBL16178358 | 0.76 | CYP2A13 (0.48) | CYP2A13CXCR4HPGDCYP2C9ALOX15 | |
| SCHEMBL8262966 | 0.75 | DHODH (0.53) | CYP2A13CXCR4HPGDCYP2C9ALOX15 | |
| SCHEMBL23122595 | 0.75 | DRD2 (0.59) | HTR1ADRD2DRD4DRD3HPGD | |
| SCHEMBL23432525 | 0.74 | GAA (0.52) | DRD2DRD4DRD3CYP2A13CYP2C9 | |
| SCHEMBL3823364 | 0.73 | PARP1 (0.46) | HTR1AHTR1DHTR1BDRD2DRD4 | |
| SCHEMBL11193326 | 0.72 | CYP2A13 (0.75) | CYP2A13CXCR4CYP2C9ALOX15HSD17B10 | |
| SCHEMBL556764 | 0.71 | PARP1 (0.51) | HTR1ADRD2DRD4DRD3HPGD | |
| SCHEMBL23123879 | 0.70 | HTR1A (0.46) | HTR1AHTR1DHTR1BDRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | Université de Montréal (CA) | 2024-07-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240239801-A1 | PYRIMIDO[5,4,D]PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM AND USES THEREOF | NRAS, BRAF, KRAS | HTR1A 4036/4885HTR1D 3053/4885HTR1B 3720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.