Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18050754 | 0.82 | HSP90AB1 (0.36) | KDM4EHSP90AB1CNR2POLBHCAR2 | |
| SCHEMBL27734476 | 0.82 | HSP90AB1 (0.36) | KDM4EHSP90AB1CNR2POLBHCAR2 | |
| SCHEMBL27836576 | 0.82 | KDR (0.43) | KDM4EHSP90AB1HMGCRKMT2AMAPT | |
| SCHEMBL29337246 | 0.79 | OPRK1 (0.43) | KDM4EPOLBHCAR2HTTKMT2A | |
| SCHEMBL15527494 | 0.77 | OPRK1 (0.50) | POLBKMT2AMAPTSMN1; SMN2GAA | |
| SCHEMBL1505655 | 0.76 | KDM4E (0.45) | KDM4EPOLBHCAR2HTTKMT2A | |
| SCHEMBL20872624 | 0.74 | OPRK1 (0.51) | KDM4ESMN1; SMN2OPRK1 | |
| SCHEMBL8478533 | 0.73 | PLK4 (0.44) | CYP3A4 | |
| SCHEMBL24852722 | 0.71 | KDM4E (0.38) | KDM4EPOLBHCAR2HTTKMT2A | |
| SCHEMBL28110438 | 0.71 | PLAU (0.40) | KDM4EPOLBHCAR2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024148191-A1 | MODULATORS OF TNF-α ACTIVITY | FORWARD THERAPEUTICS, INC. (US) | 2024-07-11 | — | — | WO | disclosed |