Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.38 |
| ▸ | DPP4 | P27487 | 9/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 9/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.33 |
| ▸ | FAP | Q12884 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518661 | 0.84 | ATM (0.53) | ATMRIPK1PIK3CDDPP4DPP8 | |
| SCHEMBL22946712 | 0.82 | CHRNB2 (0.40) | ATMRIPK1PIK3CDDPP4DPP8 | |
| SCHEMBL19577902 | 0.82 | ATM (0.39) | ATMRIPK1PIK3CDDPP4DPP8 | |
| SCHEMBL7657599 | 0.82 | ATM (0.41) | ATMRIPK1PIK3CDDPP4DPP8 | |
| SCHEMBL21801954 | 0.82 | ATM (0.41) | ATMRIPK1PIK3CDDPP4DPP8 | |
| SCHEMBL3316717 | 0.82 | ATM (0.41) | ATMRIPK1PIK3CDDPP4DPP8 | |
| SCHEMBL2993204 | 0.82 | ATM (0.41) | ATMRIPK1PIK3CDDPP4DPP8 | |
| SCHEMBL2563460 | 0.82 | ATM (0.41) | ATMRIPK1PIK3CDDPP4DPP8 | |
| SCHEMBL4303400 | 0.80 | ATM (0.39) | ATMRIPK1PIK3CDDPP4DPP8 | |
| SCHEMBL376313 | 0.80 | ATM (0.39) | ATMRIPK1PIK3CDDPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229356-A1 | 1,2-DISUBSTITUTED-4-BENZYLAMINO-PYRROLIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLI PIDEMIA OR ARTERIOSCLEROSIS | Novartis AG (CH) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009071509-A1 | 1,2-DISUBSTITUTED-4-BENZYLAMINO-PYRROLIDINE DERIVATIVES AS CETP INHIBITORS USEFUL FOR THE TREATMENT OF DISEASES SUCH AS HYPERLI PIDEMIA OR ARTERIOSCLEROSIS | NOVARTIS AG (CH) | 2009-06-11 | — | — | WO | disclosed |