Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | DPP4 | P27487 | 10/20 | 0.37 |
| ▸ | DPP8 | Q6V1X1 | 10/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 10/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | FAP | Q12884 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | BLM | P54132 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16518661 | 0.82 | ATM (0.53) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL2933741 | 0.82 | ATM (0.44) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL29243192 | 0.81 | ATM (0.34) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL29243194 | 0.81 | ATM (0.34) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL22946712 | 0.81 | CHRNB2 (0.40) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL13634276 | 0.81 | ATM (0.35) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL13360294 | 0.78 | CHRNB2 (0.43) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL19710591 | 0.78 | PIK3CD (0.59) | ATMPIK3CDDPP4DPP8DPP9 | |
| SCHEMBL13360296 | 0.78 | DPP4 (0.43) | PIK3CDDPP4DPP8DPP9DPP7 | |
| SCHEMBL22099648 | 0.75 | MEN1 (0.40) | ATMPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020236755-A2 | ANGIOTENSIN II TYPE 1 RECEPTOR TARGETED OLIGONUCLEOTIDES AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2020-11-26 | — | — | WO | disclosed |
| WO-2019092618-A9 | GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF | IONIS PHARMACEUTICALS, INC (US) | 2020-06-18 | — | — | WO | disclosed |
| WO-2017192820-A1 | GLP-1 RECEPTOR LIGAND MOIETY CONJUGATED OLIGONUCLEOTIDES AND USES THEREOF | IONIS PHARMACEUTICALS, INC. (US) | 2017-11-09 | — | — | WO | disclosed |